A Fractal Model of Protein Aggregation

Michael V. Zappitello


In biological systems, aggregates known as spherulites appear under certain conditions. While protein spherulites have been known to exist for the past 50 years, their growth kinetics and structure remain in question. I am proposing that a fractal aggregation and fractal structure are consistent with current data in the subject. Further, I have observed the growth of insulin spherulites under different temperatures and in solutions with different salts. I propose that different salts affect the fractal dimensionality of the spherulite and the discrepancies in the growth kinetics with different salts are the result of this change in fractal dimensionality.